Q1: A 54 years-old man under hydrochlorothiazide blood pressure treatment. What place represents accurately the site of action of HCTZ?
A1: Chloride-binding sites in the luminal surface of the early distal tube. So, inhibits Na-CL cotransporters -> inhibits Na-Cl reabsorption. WARNING ! SULFA ALLERGY
Focus in the mindmap:
- Everyone produce low Na-Cl-K (K except spironolactone) in blood.
- HYDROCHLOROTHIAZIDE
- HCThiazide = PTHiazide; same PTH hormone effect = hyperCALCEMIA
- Site of action: early distal tube.
Q: A 70-year-old woman comes to the physician because of a painful, swollen, and red right knee. She has a history of hypertension treated with a thiazide diuretic. Aspiration of the joint yields fluid containing basophilic rhomboid crystals. The crystals are most likely composed which crystals?
ReplyDeleteA: Calcium pyrophosphate (pseudogout). PTHiazide produces hypercalcemia