Protein synthesis

• START codon = AUG or GUG (rare)
• STOP codons = UAA, UAG, UGA
• Synthesisi of proteins activated by GTP hydrolisis
• Ribosome advance from 5' to 3' terminal
• tRNA activated by ATP

• Aminoglycosides inhibit initiation complex and produce misreading of mRNA
• Chloramphenicol inhibits 50S peptidyltransferase
• Macrolides and Clindamycin bind 50S blocking translocation

RNA processing (eukaryotes) and Splicing of mRNA

OCCURS IN THE NUCLEUS

OCCURS IN THE CYTOPLASM

• P bodies, storage and manage (regulates or turns over) the mRNA processed in the cytoplasm (UW 2035).
• LSE patients makes antibodies to splicesomal snRNPs.
• 3' splicesome terminal = AG

HIV Structure

Skeletal and Cardiac Muscle Contraction

Body Water Graphics