Wednesday, January 22, 2014

Protein synthesis


  • START codon = AUG or GUG (rare)
  • STOP codons = UAA, UAG, UGA
  • Synthesisi of proteins activated by GTP hydrolisis
  • Ribosome advance from 5' to 3' terminal
  • tRNA activated by ATP

  • Aminoglycosides inhibit initiation complex and produce misreading of mRNA
  • Chloramphenicol inhibits 50S peptidyltransferase
  • Macrolides and Clindamycin bind 50S blocking translocation

RNA processing (eukaryotes) and Splicing of mRNA

OCCURS IN THE NUCLEUS

OCCURS IN THE CYTOPLASM

  • P bodies, storage and manage (regulates or turns over) the mRNA processed in the cytoplasm (UW 2035).
  • LSE patients makes antibodies to splicesomal snRNPs.
  • 3' splicesome terminal = AG

Saturday, January 18, 2014

Glycolisis

Basics of Metabolism

Lipid Lowering Agents








  • LDL -> Statins -> +Ezetimibe
  • Cholesterol -> Ezetimibe
  • HDL -> Niacine
  • TGC -> Fibrates -> +Niacine (UW 166)

Kidney Embryology
















  • The URETERIC bud (Mesonephros) stimulates to Metanephric mesenchyma to develops:
    • Glomerulus, renal tubules to distal convulated (UW 1736).

Hematology Drugs Overview


Anemias

Leukemias


Lymphomas


Sickle Cell Anemia


  • HbS (replace aa glutamic by valine - missing mutation), causes Hb hydrophobic molecular aggregation in hypoxic, dehydratatior, or acidic conditions making polymer chains (UW 1242)