Tuesday, July 23, 2013

Hepatitis Serologic Markers

Focus in the mind map:
  • You must memorize the phrase "SEC".
  • We have two kind of things: the Agents (Ag) and the Antobodies (Ab).
  • Backing to the SEC phrase:
    • In the firs act the letter S appears first, followed by de E and the last C - valid for agents.
    • In the second act the order is inverse: first C, second E, and the last S - valid for antibodies.
  • Agent (Ag) S = CARRIER (acute or chronic).
  • Agent (Ag) E = TRANSMISSIBILITY, high on the onste like Ag, and low on the end like Ab.
  • Agent (Ag) C = IGNORED for USMLE.
  • Anti-body (Ab) S = IMMUNIZATION (vaccine or recovery).
  • Anti-body (Ab) E = commented above (low transmissibility) and window period.
  • Anti-body (Ab) C = IgM (acute), IgG (chronic) carrier, windows period, recovery.

Q1: A 56-years-old man comes with fatigue and severe jaundice. He has a history of intravenous drug abuse. Laboratory studies shows HBsAg and anti-hepatitis B core antibody (anti-HBc-G) are positive. What diagnosis has the patient using the hepatitis B serologic markers?
A1: Observe the mindmap:
  • HBsAg = Carrier (acute or chronic).
  • anti-HBc-G = IgG (chronic).
  • History & Physical = CHRONIC drug abuse user + Active hepatitis.

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